Connected sum is not cancellative
Statement
The connected sum of manifolds operation is not cancellative in any sense (up to homotopy, up to homeomorphism, up to diffeomorphism, etc.) Specifically, there is a natural number such that we can find -dimensional compact connected manifolds such that and are homeomorphic (in fact, diffeomorphic if we put a differential structure) but and are not homeomorphic or even homotopy-equivalent.
Proof
The case of
Further information: Dyck's theorem
Here, we set as the real projective plane , as the Klein bottle, and as the 2-torus. Both and are homeomorphic to what's called Dyck's surface (by a result called Dyck's theorem). However, the Klein bottle and the 2-torus and not homeomorphic -- the former is non-orientable (and hence its second homology group vanishes) and the latter is orientable (and hence its second homology group is ).